Kevin T. Mellem
Employment:
2018 to present – Senior Scientist II, Maze Therapeutics, South San Francisco, California
2018 to 2019 – Consultant, Third Rock Ventures, Redwood City, California
2016 to 2018 – Scientist II, Revolution Medicines, Redwood City, California
2014 to 2016 – Scientist, Revolution Medicines, Redwood City, California
2014 – Director of Chemistry, Midasyn Inc., Champaign, Illinois
2013 to 2014 – Postdoctoral Research Fellow, Harvard University, Cambridge, Massachusetts
Education:
2007 to 2013 – Ph.D. Studies in Organic Chemistry, Harvard University, Cambridge, Massachusetts
2002 to 2006 – B.S. Summa Cum Laude (4.00 GPA), Chemistry (minor in Economics), University of South Dakota, Vermillion, South Dakota
Publications:
“Tropolone derivatives and tautomers thereof for iron regulation in animals.” Jianhua Chao, Stanley J. Hollenbach, Michael C. Holmes, Douglas M. Matje, Nicholas M. Snead, Gustave Bergnes, Kevin T. Mellem, David J. Morgans, Jr., Walter S. Won. WO 2021076945, 2021.
“Preparation of C40- , C28- , and C32- linked rapamycin analogs as mTOR inhibitors.” Jennifer Pitzen, Micah James Evans Gliedt, Leslie G. Burnett, James Bradley Aggen, Gert Kiss, James Joseph Cregg, Christopher Michael Semko, Walter Won, Gang Wang, Julie Chu-Li Lee. WO 2019212990, 2019.
“Preparation of fused poly(hetero) cyclic compounds as allosteric SHP2 inhibitors.” Elena S. Koltun, Naing N. Aay, Andreas Buckl, Kevin T. Mellem, Brian R. Blank, Jennifer Pitzen, Gang Wang, Ashutosh Jogalekar, Walter S. Won, Christos Tzitzilonis. WO 2019118909, 2019.
“Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors and their preparation.” Jie Jack Li, Elena S. Koltun, Adrian Liam Gill, Andreas Buckl, Walter Won, Naing Aay, Kevin Mellem, Christos Tzitzilonis, Ashutosh Jogalekar, James Joseph Cregg. WO 2019075265, 2019.
"Preparation of imidazopyrazines and related bicyclic nitrogen heterocycles as allosteric SHP2 inhibitors for the treatment of diseases." Brian R. Blank, Jennifer Pitzen, Gang Wang, Walter S. Won, Christos Tzitzilonis, Jie Jack Li, Elena S. Koltun, Naing Aay, Andreas Buckl, Kevin Mellem, Christopher Semko, Ash Jogalekar, Gert Kiss, Adrian Gill. WO 2018136265, 2018.
"Preparation of pyridines as allosteric SHP2 inhibitors for treatment and prevention of diseases." Adrian Gill, Naing Aay, Kevin Mellem, Andreas Buckl, Elena S. Koltun, Christopher Semko, Gert Kiss. WO 2018136264, 2018.
“2,5-Disubstituted 3-Methylpyrazines and 2,5,6-Trisubstituted 3-Methylpyrazines as Allosteric SHP2 Inhibitors.” Ash Jogalekar, Walter Won, Elena Koltun, Adrian Gill, Kevin T. Mellem, Naing Aay, Andreas Buckl, Christopher Semko, Gert Kiss. WO2018013597, 2018.
“Preparation of Derivatives of Amphotericin B as Antifungal Agents.” Martin D Burke, Arun P. Thottumkara, Kevin T. Mellem and Zachary K. Sweeney. US 20160304548, 2016.
“On the Development of Pseudoephenamine and Its Applications in Asymmetric Synthesis.” Kevin T. Mellem. Graduate Thesis. 2013.
“A Simple, Scalable Synthetic Route to (+)- and (−)-Pseudoephenamine.” Kevin T. Mellem and Andrew G. Myers. Org. Lett. 2013, 15, DOI: 10.1021/ol402815d.
“Synthesis of α-Methyl Quaternary Amino Acids via Asymmetric Alkylation of Pseudoephenamine Alaninamide Pivaldimines.” Cedric L. Hugelshofer, Kevin T. Mellem, and Andrew G. Myers. Org. Lett. 2013, 15, 3134–3137.
“Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis.” Marvin R. Morales, Kevin T. Mellem, and Andrew G. Myers. Angewandte Chemie International Edition. 2012, 51, 4568–4571.
“Luminescence Properties and Water Coordination of Eu3+ in the Binary Solvent Mixture Water/1-Butyl-3-methylimidazolium Chloride.” Senthamizh Samikkanu, Kevin Mellem, Mary Berry, and P. Stanley May. Inorganic Chemistry. 2007, 46, 7121–7128.
“Synthesis and Characterization of Organic Light Emitting Diode (OLED) Precursors.” Kevin T. Mellem Undergraduate Thesis. 2006.
Posters and Presentations:
"Allosteric Inhibition of SHP2 variants containing cancer-associated activating mutations." David Wildes, Naing Aay, Andreas Buckl, Tientien Hsieh, Ashutosh S. Jogalekar, Gert Kiss, Elena S. Koltun, Abby Marquez, Kevin T. Mellem, Jason Romero, Mae Saldajeno-Concar, Christopher J. Schulze, Chris M. Semko, Walter Won, Robert J. Nichols, Carlos Stahlhut, Christos Tzitzilonis, Adrian L. Gill, Jacqueline A. M. Smith. AACR. 2018.
“Discovery of an allosteric inhibitor of SHP2, RMC-4550.” Elena S. Koltun, Kevin T. Mellem, Andreas Buckl, Christos Tzitzilonis, Chris M. Semko, Ashutosh S. Jogalekar, Naing N. Aay, Walter S. Won, Tientien Hsieh, Julie Lee, Steven Ballmer, Abby Marquez, Kasia Mordec, Gert Kiss, Jie Jack Li, Nidhi Tibrewal, Frances Zhao, Jeff Jasper, Jacqueline A. M. Smith, Robert J. Nichols, Susan E. Wilson, Mallika Singh, David E. Wildes, Zhengping Wang, and Adrian L. Gill. AACR. 2018.
“RMC-4550: An allosteric inhibitor optimized for in vivo studies of SHP2.” Adrian Gill, Naing Aay, Andreas Buckl, Mark Goldsmith, Ashutosh Jogalekar, Gert Kiss, Elena Koltun, Abby Marquez, Kevin Mellem, Kasia Mordec, Robert Nichols, Mae Saldajeno-Concar, Christopher Semko, Mallika Singh, Jacqueline Smith, Nidhi Tibrewal, Christos Tzitzilonis, Zhengping Wang, David Wildes, Susan Wilson, Walter Won. ACS National Meeting. 2018.
“Synthesis of New Thiophene-Containing Aluminum Complexes Relating to OLED Applications.” National Conference on Undergraduate Research. 2006.
“Synthesis of New Pyrrole-Containing Ruthenium Complexes Relating to OLED Applications.” National Conference on Undergraduate Research. 2005.
Research Experience:
2013 to 2014 – Postdoctoral Research Fellow with Professor Andrew G. Myers, Harvard University, Cambridge, Massachusetts
Synthesis of Macrolide Antibiotics
2007 to 2013 – Graduate Research Assistant with Professor Andrew G. Myers, Harvard University, Cambridge, Massachusetts
Development of Pseudoephenamine as a Chiral Auxiliary for Asymmetric Synthesis
2006 to 2007 – Post-Graduate Research Assistant with Professors P. Stanley May and Mary T. Berry, University of South Dakota, Vermillion, South Dakota
Studies of the Effect of Water Concentration on Eu3+ Luminescence and Speciation in Ionic Liquids
2004 to 2005 – Undergraduate Research Assistant with Professor Andrew G. Sykes, University of South Dakota, Vermillion, South Dakota
Synthesis and Characterization of Organic Light Emitting Diode (OLED) Precursors
Teaching Experience:
Fall 2011 – Chemistry 30, Organic Chemistry, Teaching Fellow, Harvard University
Fall 2010 – Chemistry 17, Principles of Organic Chemistry, Teaching Fellow, Harvard University
Fall 2009 – Chemistry 17, Principles of Organic Chemistry, Head Teaching Fellow, Harvard University
Fall 2008 – Chemistry 17, Principles of Organic Chemistry, Teaching Fellow, Harvard University
Spring 2008 – Chemistry 27, Organic Chemistry of Life, Teaching Fellow, Harvard University
Summer 2006 – General Chemistry, South Dakota Governor’s Camp and Ambassadors of Excellence Program, University of South Dakota
Spring 2006 – Organic Chemistry II, Supplemental Instructor, University of South Dakota
Fall 2006 – Organic Chemistry I, Supplemental Instructor, University of South Dakota
Spring 2005 – Organic Chemistry II, Supplemental Instructor, University of South Dakota
Fall 2005 – Organic Chemistry I, Supplemental Instructor, University of South Dakota
Awards and Honors:
Graduate:
Fall 2011 – Derek Bok Center Certificate of Distinction in Teaching, Chemistry 30
Fall 2010 – Derek Bok Center Certificate of Distinction in Teaching, Chemistry 17
Undergraduate:
Spring 2006 – Phi Beta Kappa Honor Society
Spring 2006 – University of South Dakota Department of Chemistry Pardee Prize
Spring 2006 – American Chemical Society Outstanding Chemistry Senior
Spring 2004 – American Chemical Society Organic Chemistry Achievement Award
Fall 2002 – National Merit Scholarship